Innovative Mechanical Preload Reduction: Transforming Heart Failure Treatment
The article “Mechanical Preload Reduction: Harnessing a Cornerstone of Heart Failure Management to Improve Clinical Outcomes” by Navin K. Kapur et al., published in ASAIO Journal, provides a comprehensive review of mechanical preload reduction (MPR) technologies as emerging therapies for heart failure management. Decongestion is a key therapeutic goal for patients with decompensated heart failure…
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Advancing Organ Viability The Role of Normothermic Regional and Machine Perfusion in Transplantation
A study delves deeply into advanced techniques for assessing donor organ viability, explicitly looking at NRP and other advanced regional organ biosensor perfusion methods. The most relevant application of these modalities is transplantation from donors after circulatory death (DCD), in which ischemic injury is a frequent barrier to transplantability. These strategies aim to optimize organ preservation and evaluation,…
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A Retrospective Study on the Long-Term Outcomes of AngioVac Procedures
The AngioVac system, a vacuum-assisted aspiration device, has proven to be an effective tool for removing right-sided cardiac thrombi and has shown utility in managing complex cases of right-sided infective endocarditis and intracardiac tumors. Despite the promising outcomes reported in the short term, there needs to be more detailed data regarding long-term patient outcomes following…
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Mannitol Is Associated with Less Postoperative Delirium after Aortic Valve Surgery in Patients Treated with Bretschneider Cardioplegia
In cardiac surgeries that use extracorporeal circulation (ECC), postoperative delirium (POD) is a common complication. This condition is associated with extended hospital stays, increased costs, and higher morbidity. According to a recent retrospective study that focused on the effects of intraoperative mannitol during aortic valve replacement (AVR), mannitol could potentially decrease the incidence of POD,…
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Standardized Definitions for Bioprosthetic Valve Dysfunction Following Aortic or Mitral Valve Replacement
In August 2022, researchers from the Quebec Heart and Lung Institute, University of Pennsylvania, U.S. Food and Drug Administration, Columbia University, University of Washington Medical Center, Beaumont Hospital, Guy’s and St Thomas’ N.H.S. Foundation Trust, Cambridge University and King’s College Hospital, University of Edinburgh (B.H.F. Centre for Cardiovascular Science), St Paul’s and Vancouver General Hospital,…
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What’s New with TAVR? An Update on Device Technology
In the past two decades, transcatheter aortic valve replacement (TAVR) has revolutionized the approach to aortic stenosis management. The technique has significantly evolved, expanding its application to younger, lower-risk patients with longer life expectancies and treating the disease at earlier stages. This progress has prompted the continuous evolution of device technology and minimized procedural complications….
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The Inspired Therapeutics Neomate MCS System for Neonates and Infants
In May 2022, scientists from the University of Louisville (Departments of Cardiovascular and Thoracic Surgery, Bioengineering, Anesthesiology, and Perioperative Medicine), Veritium research LLC, and Inspired Therapeutics LLC tested the NeoMate mechanical circulatory support (MCS) system for neonates and infants. The complete manuscript by Gretel Monreal, Steven C. Koenig, Mark S. Slaughter, Gino F. Morello, Steven…
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A Review of the Global Healthcare Simulation Economy
In February 2022, researchers from Seattle Children’s Hospital and the University of Washington School of Medicine took an in-depth look at health simulation, its economic impact, and significant hurdles to its widespread acceptance. The full manuscript, written by Taylor Sawyer, Megan M. Gray, and Rachel Umoren, is available on the Cureus website. Below is a summary of…
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Intra-Aortic Balloon Pump for Left Ventricular Unloading in VA-ECMO: Timing is Everything
An editorial published in April 2022 discusses the benefits and pitfalls of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) combined with intra-aortic balloon pumps (IABP) to manage CS. The complete manuscript, written by Agam Bansal, Dhiran Verghese, and Sarachandra Vallabhajosyula, can be found in the Journal of the American Heart Association. A summary of the editorial is…
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How Biotechnology is Impacting the Treatment and Prevention of Heart Disease
Biological processes utilization for industrial and other applications, notably gene modification of microbes for the synthesis of hormones and antibiotics is Biotechnology. Now Cardiovascular disorders are a major global public health issue, with the highest mortality and morbidity rates within all disorders. For treating and preventing heart diseases, development of drugs is now gaining importance….
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Manufacturing Perspectives in Engineering Heart Valves
Valvular heart diseases (VHD) that cause stenosis and regurgitation in heart valves, such as congenital, rheumatic, and degenerative heart illnesses, require constant clinical monitoring. Aortic or pulmonary valve anomalies are responsible for 33% of congenital heart disorders. Although patients with VHD have received transcatheter therapies and minimally invasive operations, the bulk of valve replacement surgeries…
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Novel Surfaces in Extracorporeal Membrane Oxygenation Circuits
It’s difficult to strike a balance between systemic anticoagulation and clotting. The endothelium manages the equilibrium between anticoagulant and prothrombotic systems in proper hemostasis. Because of the blood-surface interaction during ECLS, systemic anticoagulation is required to reduce the risk of clotting. UNFH has a short half-life, is easy to titrate at the bedside, and is…
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