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Variations in Information Reported Amongst Studies Regarding Coagulation in Pediatric ECMO

A study published in March assessed how outcome definitions, study population, and ECMO-, transfusion-, and coagulation- related parameters were described in pediatric ECMO studies. The complete manuscript was written by Joppe Drop, Suelyn Van Den Helm, Paul Monagle, Enno Wildschut, Matthijs de Hoog, Sabrina T.G. Gunput, Fiona Newall, Heidi J. Dalton, Graeme MacLaren, Vera Ignjatovic, and C. Heleen van Ommen. It can be found in Research and Practice in Thrombosis and Haemostasis. The significant findings are detailed below.

Extracorporeal membrane oxygenation (ECMO) is often used in children with severe refractory cardiac or pulmonary failure and has dramatically increased use with pediatric patients. Despite this, cases with hemostatic complications such as thrombosis and bleeding remain high in children. The purpose of the reported systemic review was to form a foundation for a standardized ECMO framework by assessing how ECMO-related parameters and complications were described within existing studies.


Intra-Aortic Balloon Pump for Left Ventricular Unloading in VA-ECMO: Timing is Everything

An editorial published in April 2022 discusses the benefits and pitfalls of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) combined with intra-aortic balloon pumps (IABP) to manage CS. The complete manuscript, written by Agam Bansal, Dhiran Verghese, and Sarachandra Vallabhajosyula, can be found in the Journal of the American Heart Association. A summary of the editorial is detailed below.


Anesthetic Gases in Cardiac Surgery, A Systemic Review

Isoflurane, sevoflurane, and desflurane are volatile anesthetic agents used to induce and maintain general anesthesia. In cardiac surgery, inhaled anesthetics have an additional use case in providing strong cardioprotective properties during myocardial ischemia. The use of volatile agents at a minimum alveolar concentration (MAC) of 0.5 to 2.0 during cardiac surgery results in fewer individuals needing inotropic support, reduced incidence of myocardial injury, and lower mortality than intravenous anesthesia.


Challenges Facing Women Healthcare Workers in Their Professional Growth

Despite actively striving to be promoted, women healthcare workers remain underrepresented in management and leadership roles. Women are underrepresented across the healthcare industry. This underrepresentation has been a trend for years, but it will not change without action. The industry is facing fierce competition, particularly from within the insurance sector.


Mechanical ventilation, prone positioning, and delivery in pregnant patients with severe COVID-19

In February, practitioners from the University of Maryland Department of Anesthesiology published a study on the care and outcomes of 17 pregnant COVID-19 patients who required mechanical ventilation. The full manuscript, written by Michael Wong, Shobana Bharadwaj, Allison Lankford, Jessica Galey, and Bhavani Kodali, is available on the Journal of Obstetric Anesthesia website.


Role of circulating Interleukin-7 (IL-7) and its inverse correlation with Pulmonary arterial hypertension

The team at the pediatric cardiology and critical care department at Hanover medical school in Germany, including Franziska Diekmann, Ekaterina Legchenko, Philippe Chouvarine, Ralf Lichtinghagen, Harald Bertram, Christoph M. Happel, and Georg Hansmann, recently published a study investigating the role of circulating Interleukin-7(IL-7) and its inverse correlation with the Pulmonary arterial hypertension (PAH) in humans. However, the exact mechanism of IL-7 on the severity of PAH is still unknown.


Pigmentation Affects Elastic Fiber Patterning and Biomechanical Behavior of the Murine Aortic Valve

Sana Nasim, Popular Pandey, Rosemerie M. Kanashiro-Takeuchi, Jin He, Joshua D. Hutcheson, and Lisi Kos recently published a paper looking at the relationship between aortic valve pigmentation and elasticity, building on their previously-published work. Their full manuscript is publicly available in Frontiers in Cardiovascular Medicine. Here, we summarize their findings.


Study Explores Size Ratio in Aortic Valve Leaflets and Root Using CT Imaging

This is a summary of the study conducted by Tianyang Yang, Haini Wen, Ismail El-Hamamsy, Qiming Ni, Yanbin Sun, and Dan Zhu available to read here entitled “Relationship Between Leaflets and Root in Normal Aortic Valve Based on Computed Tomography Imaging: Implication for Aortic Valve Repair” published in Frontiers in Cardiovascular Medicine in November 2021.