In May 2021, researchers from the University of Gothenburg Department of Anesthesiology and Intensive Care Medicine took an in-depth analysis of the health status of those with acute renal dysfunction due to health conditions such as early clinical septic shock, chronic renal failure, postoperative AKI, liver transplantation, and cardiac surgery with cardiopulmonary bypass. The complete manuscript, written by Sven-Erik Rickstein, Gudrun Bragadottir, Lukas Lannemyr, Bengt Redfors, and Jenny Skytte, can be found on the Kidney 360 website. The results of the study are detailed below.
The primary data set obtained by this study was renal oxygen, with its availability determined by the balance of renal oxygen delivery (RDO2) and renal oxygen consumption (RVO2). The results were then separated by the health condition contributing to acute renal dysfunction, with the following key findings.
Rickstein et al. first measured renal perfusion, filtration, and oxygenation in patients within 24-hours of hospital admittance due to early clinical septic shock. The results concluded that RDO2 was impaired in these patients due to renal vasoconstriction and the redistribution of blood flow away from the kidneys.