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The effect of cardiopulmonary bypass on blood thiamine concentration and its association with postoperative lactate concentration

There is a relationship between thiamine levels and hyperlactatemia following cardiothoracic surgery. Hyperlactatemia is commonly seen in these patients and is associated with higher morbidity and mortality rates. Lactate gets produced when anaerobic metabolism occurs, boosting its concentrations and reducing thiamine levels. Thiamine is essential for aerobic metabolism, as it is necessary for the enzyme…

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