The study “A Pharmacokinetic Framework Describing Antibiotic Adsorption to Cardiopulmonary Bypass Devices” by Conor J. O’Hanlon et al. explores how cardiopulmonary bypass (CPB) can significantly alter the pharmacokinetic (PK) parameters of antibiotics, potentially leading to therapeutic failures. Cefazolin, a commonly used beta-lactam antibiotic for antimicrobial prophylaxis during cardiac surgery with CPB, may adsorb to the…