The effect of cardiopulmonary bypass on blood thiamine concentration and its association with postoperative lactate concentration
There is a relationship between thiamine levels and hyperlactatemia following cardiothoracic surgery. Hyperlactatemia is commonly seen in these patients and is associated with higher morbidity and mortality rates. Lactate gets produced when anaerobic metabolism occurs, boosting its concentrations and reducing thiamine levels. Thiamine is essential for aerobic metabolism, as it is necessary for the enzyme…
Read
Long-Term Outcomes and Durability of Transcatheter Aortic Valve Implantation
In May 2023, researchers from Loyola University Medical Center and Houston Methodist DeBakey Heart & Vascular Center discussed the mid-to-long-term clinical outcomes observed in landmark transcatheter aortic valve implementation (TAVI) trials. They analyzed the long-term durability of transcatheter heart valves (THVs). The complete manuscript by Parth V. Desai, Sachin S. Goel, Neal S. Kleiman, and…
Read
Secretariat : The Horse with a Big Heart
Secretariat was a legendary Thoroughbred racehorse that achieved widespread acclaim for its remarkable racing career. Foaled on March 30, 1970, Secretariat is best known for winning the Triple Crown in 1973, which includes victories in the Kentucky Derby, Preakness Stakes, and Belmont Stakes. Secretariat’s Triple Crown victory remains one of the most celebrated accomplishments in…
Read
Research Developments in Pediatric Intensive Care Nutrition
Researchers from the University Medical Center Rotterdam (Research Intelligence & Strategy Unit, Department of Pediatrics, and Department of Pediatric Surgery), The Hospital for Sick Children (Division of Pediatric Gastroenterology), and the University of Toronto (Department of Pediatrics and Department of Nutritional Sciences) investigated the most prominent research topics in the field of pediatric intensive care…
Read
European Guidelines for Patient Blood Management with An Emphasis on Antifibrinolytic Drug Administration for Cardiac Surgery
Researchers from Royal Papworth Hospital, Manchester University, AP-HP Hopital Europeen Georges Pompidou, University de PARIS, Herzzentrum Dresden GmbH Universitatsklinik an der Technischen Universitat Dresden, Mater University Hospital, UCD Medical School, Oula University Hospital (Anaesthesiology and Intensive Care Medicine), Kepler University Hospital GmbH (Department of Anesthesiology and Intensive Care Medicine, University Hospitals Leuven (Department of Anesthesiology),…
Read
Single-center surgical site infection rate after peripheral ECMO decannulation and surgical repair
A Retrospective single-institution study investigated surgical site infection (SSI) rate after the decannulation of femoral Extracorporeal membrane oxygenation (ECMO), in addition to evaluating the leading risk factors for infection. The retrospective single-institutional review included patients requiring ECMO from January 2016 to October 2019. The results showed that 25% of patients developed SSI after femoral ECMO…
Read
Optimizing Perioperative Renal Replacement Therapy for Patients Undergoing Cardiac Surgical Procedures Requiring Cardiopulmonary Bypass
Researchers from Columbia University Irving Medical Center (Department of Nephrology, Department of Anesthesiology, Clinical Perfusion, and Division of Cardiac, Thoracic, and Vascular Surgery) described the unique challenges seen in patients receiving renal replacement therapy (RRT) when undergoing cardiac surgical procedures needing cardiopulmonary bypass (CPB), and various strategies used to manage this patient population safely. The…
Read
Re-dosing of Del Nido Cardioplegia In Adult Cardiac Surgery
Del Nido cardioplegia is a cardiac arrest solution developed in the early 1990s for pediatric cardiac surgery. It contains lidocaine, magnesium, and low calcium levels, making it more suitable for immature cardiac myocytes susceptible to reperfusion injury and high intracellular calcium levels following ischemia. In addition, unlike traditional blood cardioplegia, Del Nido cardioplegia is administered…
Read
Antifungal Dosing for Critically Ill Patients on ECMO
In June 2023, researchers from Royal Brompton and Harefield Hospitals, the University of Portsmouth, The Prince Charles Hospital (Adult Intensive Care Services and Critical Care Research Group), The University of Queensland, Queensland University of Technology, Bond University, University of Waterloo (School of Pharmacy), University of Utah School of Medicine (Department of Paediatrics), Imperial College London,…
Read
Impact of Cardiopulmonary Bypass Duration on Fibrinogen Replacement Efficacy Cryoprecipitate Vs. Fibrinogen Concentrate
Researchers from the University of Toronto (Department of Anesthesia and Pain Management), Peter Munk Cardiac Centre and Toronto General Hospital Research Institute, Kingston Health Sciences Centre (Department of Pathology and Molecular Medicine), Queen’s University (Department of Pathology and Molecular Medicine), and the University of Toronto (Institute of Health Policy Management and Evaluation) examined how the…
Read
Classifying Infection Risk After Pediatric Cardiac Surgery Using Trained Models
In April 2023, Vanderbilt University Medical Center researchers utilized logistic regression and machine learning methods to classify the risk of postoperative infections based on various inputs. The complete manuscript by Kaitlin C. Williamson and Daniel Fabbri is available in the AMIA Annual Symposium Proceedings Archive. Postoperative infections are frequent complications of pediatric cardiac surgery, occurring in…
Read
Recommendations for Anticoagulation Management in New-Onset Post-Cardiac Surgery Atrial Fibrillation
Researchers from Saint Mary Mercy Hospital (Department of Internal Medicine), Detroit Medical Center (Department of Internal Medicine and Department of Cardiovascular Medicine), West Virginia University (Department of Cardiology), and Thomas Jefferson University (Department of Cardiology) evaluated professional society recommendation, studies, and expert thoughts on anticoagulation management in new-onset post-cardiac surgery atrial fibrillation (PCSAF). The complete…
Read