The study by Andrew Chevalier and colleagues, published in the Journal of Extracorporeal Technology, investigates how extracorporeal life support (ECLS) circuits, specifically ECMO (extracorporeal membrane oxygenation) and CRRT (continuous renal replacement therapy), affect the pharmacokinetics of sedatives ketamine and dexmedetomidine. These medications are commonly administered to patients on ECLS for pain and sedation management.  ECLS…