In the review article titled “Positive End-Expiratory Pressure Management in Patients with Severe ARDS: Implications of Prone Positioning and Extracorporeal Membrane Oxygenation,” authored by Christoph Boesing and colleagues and published in Critical Care, the ongoing challenge in managing severe acute respiratory distress syndrome (ARDS) revolves around determining the optimal strategy for titrating positive end-expiratory pressure…