Monitoring Renal Oximetry in Donors Undergoing Normothermic Regional Perfusion After Circulatory Determination of Death
The article from ASAIO Journal provides an in-depth analysis of the use of renal oximetry, specifically regional tissue oxygen saturation (rSO2) monitoring via near-infrared spectroscopy (NIRS), in donors undergoing abdominal normothermic regional perfusion (A-NRP) following circulatory determination of death (DCD). This innovative approach involves the continuous monitoring of rSO2 to assess the balance between oxygen delivery…
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New Tool for Predicting Liver Graft Function During Normothermic Regional Perfusion
The study by Ivo J. Schurink et al., published in the EPMA Journal (The Official Journal of the European Association for Predictive, Preventive and Personalised Medicine), explores the use of the liver maximum capacity (LiMAx) test during abdominal normothermic regional perfusion (aNRP) to predict graft function in liver transplantation. The research focuses on extended criteria…
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Intraoperative Renal Perfusion Monitoring: Hyperspectral Imaging and AI in Action
In a recent study published in Scientific Reports (Nature), A. Studier-Fischer et al. explores the application of hyperspectral imaging (HSI) and artificial intelligence (AI) to intraoperative renal perfusion assessment, offering a new dimension in real-time, objective perfusion monitoring. Accurate perfusion assessment is critical for perfusionists, especially during procedures such as partial nephrectomies and kidney transplants. This…
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The discrepancies between pre-membranous and mixed venous oxygen saturation in patients on VA-ECMO undermine the accuracy of cardiac output estimation.
A recent study published in the ASAIO Journal by John, Kevin J. et al. explored the relationship between pre-membranous venous oxygen saturation (Spm-vO2) and mixed venous oxygen saturation (SvO2) in patients undergoing peripheral veno-arterial extracorporeal membrane oxygenation (VA-ECMO). The study aimed to assess the concordance between these two oxygen saturation measurements, as Spm-vO2 is continuously…
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Understanding Neutrophils in ECMO: Uncovering Their Role in Acute Organ Injury and New Therapeutic Avenues
The recent article by Mingfu Zhang and Colleagues, published in Frontiers in Immunology, presents a detailed exploration of the role of neutrophils in the acute organ injury often seen in patients undergoing extracorporeal membrane oxygenation (ECMO). ECMO is a life-saving intervention used for critically ill patients when conventional treatments are insufficient. While ECMO can stabilize…
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Platelet function is Preserved After Moderate Cardiopulmonary Bypass Times But Transiently Impaired After Protamine.
A recent study led by Mattias Törnudd and colleagues has provided new insights into the effects of cardiopulmonary bypass (CPB) on platelet function in the context of contemporary cardiac surgery. This prospective, controlled clinical study was conducted at a single-center university hospital, including 39 patients scheduled for coronary artery bypass graft surgery with CPB. The…
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Premortem Anticoagulation Timing and Dose in Donation After Circulatory Death Multicenter Study of Associations With Graft Function
This multicenter study led by Andreas H. Kramer and his colleagues delves into the critical practice of administering premortem heparin to potential organ donors in controlled donation after circulatory determination of death (DCD). Despite its widespread use, the practice remains controversial due to the potential risk of inducing bleeding and the lack of solid evidence…
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Effects of Ketone Body 3-Hydroxybutyrate on Cardiac and Mitochondrial Function During Donation After Circulatory Death Heart Transplantation
A study led by Jacob Marthinsen Seefeldt et al. explored the impact of the ketone body 3-hydroxybutyrate (3-OHB) on cardiac and mitochondrial function in the context of heart transplantation following circulatory death. The research utilized normothermic regional perfusion (NRP) to assess the effects of therapeutic interventions in donor pigs, which were later transplanted into recipient…
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Optimizing PEEP Management in Severe ARDS: The Role of Prone Positioning and ECMO
In the review article titled “Positive End-Expiratory Pressure Management in Patients with Severe ARDS: Implications of Prone Positioning and Extracorporeal Membrane Oxygenation,” authored by Christoph Boesing and colleagues and published in Critical Care, the ongoing challenge in managing severe acute respiratory distress syndrome (ARDS) revolves around determining the optimal strategy for titrating positive end-expiratory pressure…
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Efficient and Safe Aorta Cannulation in Organ Donation After Cardiac Death
Mohamed Abdullah et al. present an efficient and safe technique for cannulating a depressurized aorta during organ donation after cardiac death, utilizing thoracoabdominal normothermic regional perfusion (NRP). The procedure, performed with informed written consent from donors’ families and without needing institutional review board approval, begins after an independent physician declares death and a mandatory standoff…
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Comparing Post-Transplant Survival in Heart Transplants: Normothermic Regional Perfusion vs. Direct Procurement and Perfusion
A new study led by Gege Ran BA and colleagues examines the outcomes of heart transplants from donors after circulatory death (DCD), focusing on the two main heart procurement techniques: Normothermic Regional Perfusion (NRP) and Direct Procurement and Perfusion (DPP). Since 2019, the use of DCD hearts in transplantation has surged in the United States,…
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The Multifactorial Dynamic Perfusion Index: A Predictive Tool of Cardiac Surgery-Associated Acute Kidney Injury
Marco Ranucci and a team of dedicated colleagues have introduced a multifactorial dynamic perfusion index (MDPI) to enhance the prediction of cardiac surgery-associated acute kidney injury (CSA-AKI). This collaborative study, involving a retrospective analysis of 910 consecutive adult cardiac surgery patients, aimed to develop a dynamic predictive model that incorporates various preoperative and intraoperative risk…
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