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Role of circulating Interleukin-7(IL-7) and its inverse correlation with Pulmonary arterial hypertension

The team at the pediatric cardiology and critical care department at Hanover medical school in Germany, including Franziska Diekmann, Ekaterina Legchenko, Philippe Chouvarine, Ralf Lichtinghagen, Harald Bertram, Christoph M. Happel, and Georg Hansmann, recently published a study investigating the role of circulating Interleukin-7(IL-7)

The team at the pediatric cardiology and critical care department at Hanover medical school in Germany, including Franziska Diekmann, Ekaterina Legchenko, Philippe Chouvarine, Ralf Lichtinghagen, Harald Bertram, Christoph M. Happel, and Georg Hansmann, recently published a study investigating the role of circulating Interleukin-7(IL-7) and its inverse correlation with the Pulmonary arterial hypertension (PAH) in humans. However, the exact mechanism of IL-7 on the severity of PAH is still unknown. Their full manuscript is available on PubMed.

To better understand the pathogenesis of the PAH, an increased expression of Vascular injury markers; intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin on the surface of pulmonary endothelial cells indicate a pro-inflammatory stage with elevated cytokines and chemokines release that leads to pulmonary vascular remodeling and defective cardiovascular repair measures.

The study population is ten moderate PH patients (WHO class 2-3) and ten Controls who had a left ventricular outflow tract(n=9) or reconstruction of a double aortic arch (n=1). Both study groups had a combined left and right cardiac catheterization. There were no intracardiac or extracardiac shunts in the PH patients or the non-PH controls to guarantee a compartment-specific analysis. EDTA blood samples were collected during the cardiac catheterization from the superior vena cava, Pulmonary artery and the ascending aorta. A compartment-specific plasma concentration of IL-7, Vascular endothelial growth factor-C (VEGF-C), Aldosterone, ICAM-1, and VCAM-1 were measured.

The study reported an invasive, compartment-specific level of circulating IL-7 and VEGF-C for the first time, which showed an approximately 50% reduction in circulating IL-7 and a 59% reduction of VEGF-C plasma levels in Children with PAH, which inversely correlated with the severity of the PH.

The study also concluded a reduction in the transpulmonary gradients of ICAM-1 and VCAM-1 with higher Aldosterone levels in PH patients vs. controls.

The researchers recommended additional studies with a larger sample size to investigate the mechanisms of IL-7 and VEGF-C on the pathogenesis of PAH.

For those interested in reading more, Diekmann et al.'s full manuscript is available on PubMed.

 

 

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